CONCISE REPORT No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls
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چکیده
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls Gavin Hudson, Kalliope Panoutsopoulou, Ian Wilson, Lorraine Southam, Nigel W Rayner, Nigel Arden, Fraser Birrell, Ian Carluke, Andrew Carr, Kay Chapman, Panos Deloukas, Michael Doherty, Andrew McCaskie, William E R Ollier, Stuart H Ralston, Mike R Reed, Tim D Spector, Ana M Valdes, Gillian A Wallis, J Mark Wilkinson, Eleftheria Zeggini, David C Samuels, John Loughlin, Patrick F Chinnery, arcOGEN Consortium
منابع مشابه
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls
OBJECTIVES Osteoarthritis (OA) has a complex aetiology with a strong genetic component. Genome-wide association studies implicate several nuclear genes in the aetiology, but a major component of the heritability has yet to be defined at the molecular level. Initial studies implicate maternally inherited variants of mitochondrial DNA (mtDNA) in subgroups of patients with OA based on gender and s...
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تاریخ انتشار 2012